Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial

Objective: To determine the effectiveness of intravenousinjection granisetron compared to ondansetron inpreventing nausea and vomiting, we used MASCCAntiemesis Tool (MAT) in ovarian cancer patients undergoingpaclitaxel-carboplatin chemotherapyMethods: This study was conducted as a double-blind,randomized controlled trial. The treatment group received1 mg granisetron, whereas control received8 intravenously. Nausea vomitingwere assessed using MAT scale at 12 hours, 24 hours,and 48 hours after chemotherapy. differences MATscores between groups were analyzed Mann-Whitney test.Results: A total 60 participants enrolled thisstudy. results indicated that score 12-hour mark significantly differed from 24-hour 48-hour scores (p = 0.00, p 0.00). thegranisetron werestatistically lower =0.00, 0.00).Conclusions: In conclusion, intravenous provedto be more effective than vomiting among with ovariancancer undergoing paclitaxel-carboplatin chemotherapy.Keywords: chemotherapy, score,ondansetron, cancer.AbstrakTujuan: Mengetahui efektivitas perbandingan pemberianinjeksi intravena antara dan ondansetrondalam mencegah mual muntah dengan menggunakanMAT pada pasien kanker ovarium yang mendapatkemoterapi regimen paclitaxel-carboplatin.Metode: Penelitian ini merupakan double blind randomizedcontrolled trial kelompok perlakuan diberikangranisetron 1 kontrol diberikaninjeksi 8mg. Kemudian dilakukan penilaianterhadap menggunakan skorMAT jam, jam setelah diberikankemoterapi testkarena distribusi data tidak normal.Hasil: Total sampel penelitian adalah subjek.Hasil skor berbeda bermakna (p= 0,00, p= 0,00. Terdapatperbedaan secara statistik pengaruh terapigranisetron terhadap 24jam, 0,00).Kesimpulan: Pemberian injeksi lebihefektif dibandingkan intravenapada paclitaxel-carboplatin.Kata kunci: kemoterapi, ovarium,ondansetron, MAT.